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Many patients had been on this medication for years without exhibiting thyroid-related symptoms In contrast, others are started at low doses between 25mcg-50mcg/day and titrated up as necessary. I'm concerned how serious this could effect me It can take a few days to a few weeks for you to even start noticing a difference in how you feel. The body can survive for many years without a thyroid gland. Products such as iron and calcium supplements and antacids can lower your body’s ability to absorb levothyroxine, so SYNTHROID should be taken 4 hours before or after taking these products Oct 4, 2018 at 7:34 PM. While there isn’t an exact amount of time that you can safely go without pooping. If you think you may have a medical emergency, call your physician or 911 immediately I asked if they could get me a refill and they said no. However, it’s connected to many aspects of your lifestyle, including stress and dietary and exercise habits. 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